By Hans-Jürgen Bässler, Frank Lehmann
This ebook covers all facets of containment expertise extensive and the most recent advancements during this interesting box are brought. This publication is a key booklet to making plans engineers, construction managers and people attracted to getting an image of the various functions of the isolator expertise. References on literature, legislation, norms and guidance will aid the reader to turn into conversant in the containment technology.
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Extra info for Containment Technology: Progress in the Pharmaceutical and Food Processing Industry
Explosion protection is a cost factor in every project and needs therefore a precise definition during the pre-design phase to avoid additional cost and time delays during the project design and construction phases. 3 Negative Pressure Glove Box for Pharmaceutical Applications The application possibilities for negative pressure glove boxes are various. In the laboratory, they are used for the safe handling of toxic and more active powdery substances (Fig. 6). Typical activities are weighing and sample acquisition, assembly of small components, and product transfer.
The vacuum cleaner is attached to the isolator with a Banjo split ball valve. This valve allows disconnecting the vacuum cleaner without carrying out hazardous dust to the environment. In a second step, the WIP system with spray balls from the bottom and from the ceiling washes both isolator sections with an adequate wash program. The waste water is drained through a bottom seat valve into the waste water collection tank and afterward discarded. When the isolator and the encapsulated machine parts are visually clean, the isolator can be opened and the drying is done manually with wipes.
The equipment in the field of ‘‘cell’’ technology, such as filling lines, opening and closing systems and measurement technology, is customer—and application specific and must be prepared for the special handling with corresponding manipulators. The processes are mostly operated with interchangeable modular systems. Necessary pressure and zoning classifications are based largely on the volatility of the processed substances and the risk to operators and to the environment from radioactive substances.