ACM transactions on information systems (January) by Association for Computing Machinery PDF

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Since these errors result in noise and increase the dimensionality of the data, our first preprocessing step is error removal. ACM Transactions on Information Systems, Vol. 23, No. 1, January 2005. 42 • J. Sander et al. Within one library, up to 80% of the unique tags have a frequency of 1, but these make up about 20% of the total number of copies of tags. Some of the single frequency tags represent genuine low frequency mRNAs. However, it is impossible to tell which of the single frequency tags are errors by only looking at a single library.

In Genome Informatics Workshop. Universal Academy Press, 43–52. PEARSON, W. AND LIPMAN, D. 1988. Improved tools for biological sequence comparison. In Proc. Natl. Acad. Sci. USA. Vol. 85. 2444–2448. RISSANEN, J. 1976. Generalized Kraft inequality and arithmetic coding. IBM J. Res. Dev. 20, 3, 198–203. , AND DELGRANGE, O. 1995. A guaranteed compression scheme for repetitive DNA sequences. Tech. Rep. IT–285, LIFL Lille I Univ. , AND RISSANEN, J. 2003a. DNA sequence compression using the normalized maximum likelihood model for discrete regression.

Result of OPTICS on the subspace selected by the Wilcoxon test including error removal, normalization, and missing tag imputation. ACM Transactions on Information Systems, Vol. 23, No. 1, January 2005. 52 • J. Sander et al. that these two cancers may be related in some way. Furthermore, the ovarian libraries and the brain libraries were produced by two different laboratories. In a later section, we will investigate why these two types of cancers clustered together and which tags they are similar for.

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